Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration
Identifieur interne : 006743 ( Main/Exploration ); précédent : 006742; suivant : 006744Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration
Auteurs : Hirotaka Suga [Japon] ; Jun Araki [Japon] ; Noriyuki Aoi [Japon] ; Harunosuke Kato [Japon] ; Takuya Higashino [Japon] ; Kotaro Yoshimura [Japon]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2009-12.
Abstract
Lipedema is a disease with unknown etiology presenting as bilateral and symmetric enlargement of the lower extremities due to subcutaneous deposition of the adipose tissue. Here we describe the histopathological features of the lipedema tissue and nonaffected adipose tissue obtained from a typical patient with severe lipedema. Immunohistochemical analyses indicated degenerative and regenerative changes of the lipedema tissue, characterized by crown‐like structures (necrotizing adipocytes surrounded by infiltrating CD68+ macrophages; a feature commonly seen in obese adipose tissue) and proliferation of adipose‐derived stem/progenitor/stromal cells (Ki67+CD34+ cells), respectively. These findings suggested increased adipogenesis in the lipedema tissue, which may further lead to hypoxia similar to that seen in obesity, resulting in adipocyte necrosis and macrophage recruitment. The confinement to the lower extremities and the difference from systemic obesity warrants further elucidation in future studies.
Url:
DOI: 10.1111/j.1600-0560.2009.01256.x
Affiliations:
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symmetric enlargement of the lower extremities due to subcutaneous deposition of the adipose tissue. Here we describe the histopathological features of the lipedema tissue and nonaffected adipose tissue obtained from a typical patient with severe lipedema. Immunohistochemical analyses indicated degenerative and regenerative changes of the lipedema tissue, characterized by crown‐like structures (necrotizing adipocytes surrounded by infiltrating CD68+ macrophages; a feature commonly seen in obese adipose tissue) and proliferation of adipose‐derived stem/progenitor/stromal cells (Ki67+CD34+ cells), respectively. These findings suggested increased adipogenesis in the lipedema tissue, which may further lead to hypoxia similar to that seen in obesity, resulting in adipocyte necrosis and macrophage recruitment. 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